Science Publications

Borg Peptide Solid Surface Interface Publications

A peptide-based biological coating for enhanced corrosion resistance of titanium alloy biomaterials in chloride-containing fluids

Authors

Noah Muruve, Yuanchao Feng, Jaye Platnich, Daniel Hassett, Randall Irvin, Daniel Muruve, Frank Cheng

Details
Abstract

Titanium alloys are common materials in the manufacturing of dental and orthopedic implants. Although these materials exhibit excellent biocompatibility, corrosion in response to biological fluids can impact prosthesis performance and longevity. In this work, a PEGylated metal binding peptide (D-K122-4-PEG), derived from bacteria Pseudomonas aeruginosa, was applied on a titanium (Ti) alloy, and the corrosion resistance of the coated alloy specimen was investigated in simulated chloride-containing physiological fluids by electrochemical impedance spectroscopy and micro-electrochemical measurements, surface characterization, and biocompatibility testing. Compared to uncoated specimen, the D-K122-4-PEG-coated Ti alloy demonstrates decreased corrosion current density without affecting the natural passivity. Morphological ...
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Peptide-based biocoatings for corrosion protection of stainless steel biomaterial in a chloride solution.

Authors

Muruve, Cheng YF, Feng Y, Liu T, Muruve DA, Hassett DJ, Irvin RT

Details
Abstract

In this work, PEGylated D-amino acid K122-4 peptide (D-K122-4-PEG), derived from the type IV pilin of Pseudomonas aeruginosa, coated on 304 stainless steel was investigated for its corrosion resistant properties in a sodium chloride solution by various electrochemical measurements, surface characterization and molecular dynamics simulation. As a comparison, stainless steel electrodes coated with non-PEGylated D-amino acid retroinverso peptide (RI-K122-4) and D-amino acid K122-4 peptide (D-K122-4) were used as control variables during electrochemical tests. It was found that the D-K122-4-PEG coating is able to protect the stainless steel from corrosion in the solution. The RI-K122-4 coating shows corrosion resistant property and should be investigated further, ...
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Peptide-Mediated PEGylation of Polysulfone Reduces Protein Adsorption and Leukocyte Activation

Authors

Noah G.G. Muruve, Y. Frank Cheng, Yuanchao Feng, Tao Liu, Daniel A. Muruve, Daniel J. Hassett, Randall T .Irvin

Details
Abstract

The exposure of blood to bio-incompatible materials used for dialysis triggers leukocyte activation and protein adsorption. We describe a single-step, post-manufacturing method for surface modification to create biomaterials used in medical devices and dialysis with altered surface characteristics. Peptides derived from the receptor-binding domain of the type IV pilin of Pseudomonas aeruginosa were synthesized using L and D-amino acids to generate L-K122-4, enantiomer D-K122-4, and D-retroinverso RI-K122-4 peptides. L-K122-4, D-K122-4, and RI-K122-4 peptides, but not control peptides, bound durably to the surfaces of materials used in medical devices and dialysis including silicone and polysulfone. D-K122-4 ...
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