Treating organ inflammation

LSALT peptide (Metablok) is designed to target acute organ inflammation in the lungs, liver and kidneys.

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Arch Biopartners Science

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The Company

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Developing drugs to prevent inflammation and organ injury

Arch Biopartners is a late-stage clinical trial company focused on preventing inflammation and organ injury.

Organ inflammation is a frequent result of common injuries and diseases and presents an unmet need with no effective treatments in the market today.

Arch has built a novel, therapeutic drug platform of new candidates led by LSALT peptide, developed to inhibit inflammation in the lungs, liver, and kidneys via the dipeptidase-1 (DPEP1) pathway.

Arch Biopartners Approach

The company has a long history of working closely with the scientific community, universities and research institutions. Arch Biopartners mission is to advance and build the value of select therapeutic innovations, develop the most promising intellectual property, and create value for its investors.

Find out more about the Company, our focus and the fundamentals that make Arch unique.

Arch Biopartners Submits Application to the Turkish Ministry of Health to Conduct a Phase II Cardiac Surgery Associated-Acute Kidney Injury Trial for LSALT Peptide

TORONTO, Sept. 22, 2023 (GLOBE NEWSWIRE) -- Arch Biopartners Inc., (“Arch” or the “Company”) (TSX Venture: ARCH and OTCQB: ACHFF), announced that it has submitted applications to the Ministry of Health (MoH) and local Ethics Committee in Turkey to obtain permission to proceed with a Phase II trial for LSALT peptide, targeting the prevention and treatment of cardiac surgery-associated acute kidney injury (CS-AKI). LSALT peptide is the Company’s lead drug candidate for preventing and treating inflammation injury in the kidneys, lungs and liver.   This ...

Arch Biopartners Engages Independent Trading Group as Market Maker

July 31, 2023 18:02 ET | Source: Arch Biopartners TORONTO, July 31, 2023 (GLOBE NEWSWIRE) -- Arch Biopartners Inc., (“Arch” or the “Company”) (TSX Venture: ARCH and OTCQB: ACHFF), announced today that it has engaged the services of Independent Trading Group (“ITG”) to provide market-making services in accordance with TSX Venture Exchange (TSXV) policies, subject to regulatory approval. ITG will trade shares of the Company on the TSXV and all other trading venues with the objective of maintaining a reasonable market and improving the ...
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Latest Scientific Publications

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Developing select technologies

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LSALT Peptide (Metablok), is the company’s lead drug candidate targeting organ inflammation in the lungs, liver and kidneys.
LSALT peptide trials and development

In 2023, the company produced new human safety and efficacy data in a Phase I dose escalation study and announced that it has received FDA permission to proceed with a new Phase II human trial targeting organ inflammation in other applications such as cardiac surgery-associated kidney injury (CS-AKI).

Previous Phase II and III trials during the pandemic accelerated Arch’s drug development plans and shortened the path toward the approval and commercialization of LSALT peptide. Inflammation in the lungs was a common complication of hospitalized pandemic patients and LSALT peptide was used for the first time in a Phase II trial to treat acute lung inflammation in that setting. Successful results accelerated LSALT peptide’s inclusion in a national Phase III trial in Canada looking for new treatments to treat acute lung inflammation in the later stages of the pandemic.

Find out more about our science platforms and about LSALT peptide development and human trials targeting organ inflammation.

An experienced group of scientists working together to develop the Arch science platforms.
Science and Research Teams
  • Current work on LSALT Peptide is directed by Arch’s larger Treatments for Inflammation Team, led by Dr. Daniel Muruve Ph. D. (Arch Biopartners CSO), Dr. Justin Macdonald Ph. D., and Dr. Arthur Lau Ph. D (Arch Biopartners Project Director), who are primarily based at the University of Calgary.
  • The DPEP1 Inflammation Pathway and LSALT Peptide (Metablok) were discovered by the Metablok team – Dr. Stephen Robbins Ph. D., Dr. Donna Senger Ph. D., Jennifer Rahn B Sc., M Sc. and their colleague Dr. Paul Kubes at the University of Calgary.

The Arch science team also includes:

The Arch Biopartners Science Teams have all participated and authored key papers and journal publications as a core part of their ongoing scientific research, discoveries and development.
  • Treatments for Inflammation publications surrounding the development of LSALT Peptide (Metablok) as a treatment for inflammation with broad application to prevent organ and tissue injury
  • AB569 publications describing AB569 as a novel bactericidal treatment for treatment resistant bacteria and Respiratory Pseudomonas
  • BORG Peptide publications discussing a peptide-based biological coating for enhanced corrosion resistance, strength and control of adhesion of bacteria and microbes.
  • Brain Tumor Stem Cell Targeting publications describe the development of a peptide-based delivery platform for targeting malignant brain tumors