Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury

Published in the AAAS journal Science Advances this paper by key members of the Arch Biopartners scientific team led by Dr. Daniel Muruve at the University of Calgary, and their collaborators, demonstrated the mechanism by which DPEP-1 regulates the recruitment of leukocytes (i.e. inflammation) to the kidney following ischemia reperfusion injury, which is injury that … Read more

Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver

Authors Saurav Roy Choudhury, Liane Babes, Jennifer J. Rahn, Bo-Young Ahn, Kimberly-Ann R. Goring, Jennifer C. King, Arthur Lau, Björn Petri, Xiaoguang Hao, Andrew K. Chojnacki, Ajitha Thanabalasuriar, Erin F. McAvoy, Sébastien Tabariès, Christoph Schraeder, Kamala D. Patel, Peter M. Siegel, Karen A. Kopciuk, David C. Schriemer, Daniel A. Muruve, Margaret M. Kelly, Bryan G. … Read more

The NLRP3 inflammasome promotes renal inflammation and contributes to CKD

Authors Akosua Vilaysane, Justin Chun, Mark E. Seamone, Wenjie Wang, Rick Chin, Simon Hirota, Yan Li, Sharon A. Clark, Jurg Tschopp, Kiril Trpkov, Brenda R. Hemmelgarn, Paul L. Beck, and Daniel A. Muruve Details First Published in the Journal of the American Society of Nephrology (JASN) August 5, 2010, J Am Soc Nephrol. 2010 Oct;21(10):1732-44. … Read more

Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome

Authors Jeffrey Ng 1, Simon A Hirota, Olaf Gross, Yan Li, Annegret Ulke-Lemee, Mireille S Potentier, L Patrick Schenck, Akosua Vilaysane, Mark E Seamone, Hanping Feng, Glen D Armstrong, Jurg Tschopp, Justin A Macdonald, Daniel A Muruve, Paul L Beck Overview First published in the American Gastroenterology Association (AGA) journal, Gastroenterology, April 13 2010Gastroenterology. 2010 … Read more