Treatments for Inflammation

Published in the peer-reviewed journal of the National Kidney Foundation, Kidney Medicine (December 2024), this meta-analysis led by Dr. Matthew T. James and colleagues systematically reviewed human clinical data evaluating cilastatin’s potential nephroprotective effects in people at risk of acute kidney injury (AKI). The study supports the clinical rationale for cilastatin, a well-established inhibitor of … Read more

Published in the peer reviewed journal BMJ Open (March 2024, Vol 14, Issue 3), this paper by key members of the Arch Biopartners scientific team, led by Dr. Daniel Muruve at the University of Calgary, and their collaborators, describes the clinical highlights, outcomes and biomarker results of the study. The results of the Phase II … Read more

Published in the AAAS journal Science Advances this paper by key members of the Arch Biopartners scientific team led by Dr. Daniel Muruve at the University of Calgary, and their collaborators, demonstrated the mechanism by which DPEP-1 regulates the recruitment of leukocytes (i.e. inflammation) to the kidney following ischemia reperfusion injury, which is injury that … Read more

Authors Saurav Roy Choudhury, Liane Babes, Jennifer J. Rahn, Bo-Young Ahn, Kimberly-Ann R. Goring, Jennifer C. King, Arthur Lau, Björn Petri, Xiaoguang Hao, Andrew K. Chojnacki, Ajitha Thanabalasuriar, Erin F. McAvoy, Sébastien Tabariès, Christoph Schraeder, Kamala D. Patel, Peter M. Siegel, Karen A. Kopciuk, David C. Schriemer, Daniel A. Muruve, Margaret M. Kelly, Bryan G. … Read more

Authors Arthur Lau, Hyunjae Chung, Takanori Komada, Jaye M. Platnich, Christina F. Sandall, Saurav Roy Choudhury, Justin Chun, Victor Naumenko, Bas G.J. Surewaard, Michelle C. Nelson, Annegret Ulke-Lemée, Paul L. Beck, Hallgrimur Benediktsson, Anthony M. Jevnikar, Sarah L. Snelgrove, Michael J. Hickey, Donna L. Senger, Matthew T. James, Justin A. Macdonald, Paul Kubes, Craig N. … Read more

Authors Simon A. Hirota, PhD, Jeffrey Ng, MSc, Alan Lueng, Maitham Khajah, PhD, Ken Parhar, MD, Yan Li, MSc, Victor Lam, BSc, Mireille S. Potentier, Kelvin Ng, Misha Bawa, BSc, Donna-Marie McCafferty, PhD, Kevin P. Rioux, MD, PhD, Subrata Ghosh, MD, Ramnik J. Xavier, MD, Sean P. Colgan, PhD, Jurg Tschopp, PhD, Daniel Muruve, MD, … Read more

Authors Akosua Vilaysane, Justin Chun, Mark E. Seamone, Wenjie Wang, Rick Chin, Simon Hirota, Yan Li, Sharon A. Clark, Jurg Tschopp, Kiril Trpkov, Brenda R. Hemmelgarn, Paul L. Beck, and Daniel A. Muruve Details First Published in the Journal of the American Society of Nephrology (JASN) August 5, 2010, J Am Soc Nephrol. 2010 Oct;21(10):1732-44. … Read more

Authors Jeffrey Ng 1, Simon A Hirota, Olaf Gross, Yan Li, Annegret Ulke-Lemee, Mireille S Potentier, L Patrick Schenck, Akosua Vilaysane, Mark E Seamone, Hanping Feng, Glen D Armstrong, Jurg Tschopp, Justin A Macdonald, Daniel A Muruve, Paul L Beck Overview First published in the American Gastroenterology Association (AGA) journal, Gastroenterology, April 13 2010Gastroenterology. 2010 … Read more