Treatments for Inflammation Publications
Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury
Authors
Arthur Lau, Hyunjae Chung, Takanori Komada, Jaye M. Platnich, Christina F. Sandall, Saurav Roy Choudhury, Justin Chun, Victor Naumenko, Bas G.J. Surewaard, Michelle C. Nelson, Annegret Ulke-Lemée, Paul L. Beck, Hallgrimur Benediktsson, Anthony M. Jevnikar, Sarah L. Snelgrove, Michael J. Hickey, Donna L. Senger, Matthew T. James, Justin A. Macdonald, Paul Kubes, Craig N. Jenne, Daniel A. Muruve
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Abstract
Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying pathogenesis is poorly understood. Nod-like receptor pyrin containing 3–deficient (Nlrp3-deficient) mice displayed reduced epithelial cell injury and inflammation in the kidney in a model of contrast-induced AKI ...
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
Authors
Simon A. Hirota, PhD, Jeffrey Ng, MSc, Alan Lueng, Maitham Khajah, PhD, Ken Parhar, MD, Yan Li, MSc, Victor Lam, BSc, Mireille S. Potentier, Kelvin Ng, Misha Bawa, BSc, Donna-Marie McCafferty, PhD, Kevin P. Rioux, MD, PhD, Subrata Ghosh, MD, Ramnik J. Xavier, MD, Sean P. Colgan, PhD, Jurg Tschopp, PhD, Daniel Muruve, MD, Justin A. MacDonald, PhD, Paul L. Beck, MD, PhD
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Abstract
BACKGROUND: Attenuated innate immune responses to the intestinal microbiota have been linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that ...
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD
Authors
Akosua Vilaysane, Justin Chun, Mark E. Seamone, Wenjie Wang, Rick Chin, Simon Hirota, Yan Li, Sharon A. Clark, Jurg Tschopp, Kiril Trpkov, Brenda R. Hemmelgarn, Paul L. Beck, and Daniel A. Muruve
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Abstract
Inflammation significantly contributes to the progression of chronic kidney disease (CKD). Inflammasome-dependent cytokines, such as IL-1β and IL-18, play a role in CKD, but their regulation during renal injury is unknown. Here, we analyzed the processing of caspase-1, IL-1β, and IL-18 after unilateral ureteral obstruction (UUO) in mice, which suggested activation of the Nlrp3 inflammasome during renal injury. Compared with wild-type mice, Nlrp3(-/-) ...
