Science Publications

Recent Publications

Development of a peptide-based delivery platform for targeting malignant brain tumors

Authors

Jennifer J. Rahna,b,d, Xueqing Luna,b,d, Selina K. Jorchc,e, Xiaoguang Haoa,b,d, Chitra Venugopalg, Parvez Vorag, Bo Young Ahna,b,d, Liane Babesa,b,d, Mana M. Alshehria,b,d,1, J. Gregory Cairncrossa,b,f, Sheila K. Singhg, Paul Kubesc,e, Donna L. Sengera,b,d,∗∗, Stephen M. Robbinsa,b,d,∗

a Arnie Charbonneau Cancer Institute, University of Calgary
b Clark H. Smith Brain Tumour Centre, University of Calgary
c Calvin, Phoebe & Joan Snyder Institute For Chronic Diseases, University of Calgary
d Departments of Oncology, University of Calgary
e Physiology and Pharmacology, University of Calgary
f Clinical Neurosciences, University of Calgary
g Department of Surgery, McMaster Children's Hospital, And McMaster Stem Cell and Cancer Research Institute, McMaster University

Details
Abstract

Despite extensive molecular characterization, human glioblastoma remains a fatal disease with ...
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AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria

Authors

Cameron T. McDaniel, Warunya Panmanee, Geoffrey L. Winsor, Erin Gill, Claire Bertelli, Michael J. Schurr, Prateek Dongare, Andrew T. Paul, Seung-Hyun B. Ko, Gee W. Lau, Nupur Dasgupta, Amy L. Bogue, William E. Miller, Joel E. Mortensen, David B. Haslam, Phillip Dexheimer, Daniel A. Muruve, Bruce J. Aronow, Malcolm D. E. Forbes, Marek Danilczuk, Fiona S. L. Brinkman, Robert E. W. Hancock, Thomas J. Meyer, and Daniel J. Hassett

Details

Antibiotic-resistant superbug bacteria represent a global health problem with no imminent solutions. Here we demonstrate that the combination (termed AB569) of acidified nitrite (A-NO2−) and Na2-EDTA (disodium ethylenediaminetetraacetic acid) inhibited all Gram-negative and Gram-positive bacteria tested. AB569 was also efficacious at killing the model organism Pseudomonas aeruginosa in biofilms and in ...
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Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver

Authors

Saurav Roy Choudhury, Liane Babes, Jennifer J. Rahn, Bo-Young Ahn, Kimberly-Ann R. Goring, Jennifer C. King, Arthur Lau, Björn Petri, Xiaoguang Hao, Andrew K. Chojnacki, Ajitha Thanabalasuriar, Erin F. McAvoy, Sébastien Tabariès, Christoph Schraeder, Kamala D. Patel, Peter M. Siegel, Karen A. Kopciuk, David C. Schriemer, Daniel A. Muruve, Margaret M. Kelly, Bryan G. Yipp, Paul Kubes, Stephen M. Robbins, Donna L. Senger

Details
Highlights
  • Dipeptidase 1 (DPEP1) serves as a vascular adhesion molecule in lungs and liver
  • DPEP1 acts as a physical adhesion receptor independent of its dipeptidase activity
  • Targeting DPEP1 reduces mortality in murine models of sepsis
Abstract

A hallmark feature of inflammation is the orchestrated recruitment ...
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